Integrin-binding sialoprotein (IBSP)

About Integrin-binding sialoprotein

Integrin-binding sialoprotein (IBSP) is a protein from Homo sapiens identified by UniProt accession P21815, 317 residues long. MolForge cross-references it against 0 known binders and 498 disease associations.

Target properties

Protein name	Integrin-binding sialoprotein
UniProt accession	P21815
Gene	IBSP
Organism	Homo sapiens
Length	317 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (498)

Diseases linked to this target (Open Targets).

body height · score 0.43
heel bone mineral density · score 0.33
neurodegenerative disease · score 0.32
breast adenocarcinoma · score 0.23
blood phosphate measurement · score 0.22
bone density · score 0.17
Cystic Kidney Disease · score 0.15
Genetic renal or urinary tract malformation · score 0.15
lean body mass · score 0.14
appendicular lean mass · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P21815-F1	alphafold	PREDICTED	49.89	—

Amino-acid sequence (317 residues)

MKTALILLSI LGMACAFSMK NLHRRVKIED SEENGVFKYR PRYYLYKHAY FYPHLKRFPV QGSSDSSEEN GDDSSEEEEE EEETSNEGEN NEESNEDEDS EAENTTLSAT TLGYGEDATP GTGYTGLAAI QLPKKAGDIT NKATKEKESD EEEEEEEEGN ENEESEAEVD ENEQGINGTS TNSTEAENGN GSSGGDNGEE GEEESVTGAN AEDTTETGRQ GKGTSKTTTS PNGGFEPTTP PQVYRTTSPP FGKTTTVEYE GEYEYTGANE YDNGYEIYES ENGEPRGDNY RAYEDEYSYF KGQGYDGYDG QNYYHHQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards