B-cell differentiation antigen CD72 (CD72)

About B-cell differentiation antigen CD72

B-cell differentiation antigen CD72 (CD72) is a protein from Homo sapiens identified by UniProt accession P21854, 359 residues long. MolForge cross-references it against 0 known binders and 261 disease associations.

Target properties

Protein name	B-cell differentiation antigen CD72
UniProt accession	P21854
Gene	CD72
Organism	Homo sapiens
Length	359 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (261)

Diseases linked to this target (Open Targets).

mean platelet volume · score 0.22
coronary artery disease · score 0.16
lung adenocarcinoma · score 0.10
common variable immunodeficiency · score 0.08
isolated agammaglobulinemia · score 0.07
ICF syndrome · score 0.07
Systemic lupus erythematosus · score 0.07
autoimmune disease · score 0.07
immunodeficiency 62 · score 0.07
immunodeficiency 72 with autoinflammation · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P21854-F1	alphafold	PREDICTED	76.09	—

Amino-acid sequence (359 residues)

MAEAITYADL RFVKAPLKKS ISSRLGQDPG ADDDGEITYE NVQVPAVLGV PSSLASSVLG DKAAVKSEQP TASWRAVTSP AVGRILPCRT TCLRYLLLGL LLTCLLLGVT AICLGVRYLQ VSQQLQQTNR VLEVTNSSLR QQLRLKITQL GQSAEDLQGS RRELAQSQEA LQVEQRAHQA AEGQLQACQA DRQKTKETLQ SEEQQRRALE QKLSNMENRL KPFFTCGSAD TCCPSGWIMH QKSCFYISLT SKNWQESQKQ CETLSSKLAT FSEIYPQSHS YYFLNSLLPN GGSGNSYWTG LSSNKDWKLT DDTQRTRTYA QSSKCNKVHK TWSWWTLESE SCRSSLPYIC EMTAFRFPD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards