About Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SDHB) is a protein
from Homo sapiens identified by UniProt accession
P21912, 280 residues long.
MolForge cross-references it against 0 known binders and
339 disease associations.
Target properties
| Protein name | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial |
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| UniProt accession | P21912 |
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| Gene | SDHB |
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| Organism | Homo sapiens |
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| Length | 280 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (339)
Diseases linked to this target (Open Targets).
- Carney-Stratakis syndrome · score 0.80
- mitochondrial complex 2 deficiency, nuclear type 4 · score 0.78
- adrenal gland pheochromocytoma · score 0.78
- gastrointestinal stromal tumor · score 0.76
- Paraganglioma · score 0.75
- hereditary pheochromocytoma-paraganglioma · score 0.71
- hereditary neoplastic syndrome · score 0.57
- Inherited cancer-predisposing syndrome · score 0.57
- Cowden disease · score 0.41
- mitochondrial complex II deficiency, nuclear type 1 · score 0.40
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P21912-F1 | alphafold | PREDICTED | 91.34 | — |
Amino-acid sequence (280 residues)
MAAVVALSLR RRLPATTLGG ACLQASRGAQ TAAATAPRIK KFAIYRWDPD KAGDKPHMQT YEVDLNKCGP MVLDALIKIK NEVDSTLTFR RSCREGICGS CAMNINGGNT LACTRRIDTN LNKVSKIYPL PHMYVIKDLV PDLSNFYAQY KSIEPYLKKK DESQEGKQQY LQSIEEREKL DGLYECILCA CCSTSCPSYW WNGDKYLGPA VLMQAYRWMI DSRDDFTEER LAKLQDPFSL YRCHTIMNCT RTCPKGLNPG KAIAEIKKMM ATYKEKKASV
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