Matrilin-1 (MATN1)

About Matrilin-1

Matrilin-1 (MATN1) is a protein from Homo sapiens identified by UniProt accession P21941, 496 residues long. MolForge cross-references it against 0 known binders and 88 disease associations.

Target properties

Protein name	Matrilin-1
UniProt accession	P21941
Gene	MATN1
Organism	Homo sapiens
Length	496 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (88)

Diseases linked to this target (Open Targets).

body height · score 0.43
monocyte count · score 0.39
myeloid white cell count · score 0.25
high density lipoprotein cholesterol measurement · score 0.24
breast adenocarcinoma · score 0.20
adolescent idiopathic scoliosis · score 0.18
platelet crit · score 0.17
leukocyte count · score 0.14
nose morphology measurement · score 0.10
peak expiratory flow · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P21941-F1	alphafold	PREDICTED	83.11	—

Amino-acid sequence (496 residues)

MRVLSGTSLM LCSLLLLLQA LCSPGLAPQS RGHLCRTRPT DLVFVVDSSR SVRPVEFEKV KVFLSQVIES LDVGPNATRV GMVNYASTVK QEFSLRAHVS KAALLQAVRR IQPLSTGTMT GLAIQFAITK AFGDAEGGRS RSPDISKVVI VVTDGRPQDS VQDVSARARA SGVELFAIGV GSVDKATLRQ IASEPQDEHV DYVESYSVIE KLSRKFQEAF CVVSDLCATG DHDCEQVCIS SPGSYTCACH EGFTLNSDGK TCNVCSGGGG SSATDLVFLI DGSKSVRPEN FELVKKFISQ IVDTLDVSDK LAQVGLVQYS SSVRQEFPLG RFHTKKDIKA AVRNMSYMEK GTMTGAALKY LIDNSFTVSS GARPGAQKVG IVFTDGRSQD YINDAAKKAK DLGFKMFAVG VGNAVEDELR EIASEPVAEH YFYTADFKTI NQIGKKLQKK ICVEEDPCAC ESLVKFQAKV EGLLQALTRK LEAVSKRLAI LENTVV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards