About 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial (BCKDHB) is a protein
from Homo sapiens identified by UniProt accession
P21953, 392 residues long.
MolForge cross-references it against 0 known binders and
79 disease associations.
Target properties
| Protein name | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial |
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| UniProt accession | P21953 |
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| Gene | BCKDHB |
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| Organism | Homo sapiens |
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| Length | 392 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (79)
Diseases linked to this target (Open Targets).
- maple syrup urine disease type 1B · score 0.76
- maple syrup urine disease · score 0.75
- maple syrup urine disease type 1A · score 0.69
- genetic disorder · score 0.48
- body height · score 0.44
- appendicular lean mass · score 0.43
- lean body mass · score 0.43
- BMI-adjusted waist-hip ratio · score 0.42
- sitting height measurement · score 0.38
- classic maple syrup urine disease · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P21953-F1 | alphafold | PREDICTED | 90.56 | — |
Amino-acid sequence (392 residues)
MAVVAAAAGW LLRLRAAGAE GHWRRLPGAG LARGFLHPAA TVEDAAQRRQ VAHFTFQPDP EPREYGQTQK MNLFQSVTSA LDNSLAKDPT AVIFGEDVAF GGVFRCTVGL RDKYGKDRVF NTPLCEQGIV GFGIGIAVTG ATAIAEIQFA DYIFPAFDQI VNEAAKYRYR SGDLFNCGSL TIRSPWGCVG HGALYHSQSP EAFFAHCPGI KVVIPRSPFQ AKGLLLSCIE DKNPCIFFEP KILYRAAAEE VPIEPYNIPL SQAEVIQEGS DVTLVAWGTQ VHVIREVASM AKEKLGVSCE VIDLRTIIPW DVDTICKSVI KTGRLLISHE APLTGGFASE ISSTVQEECF LNLEAPISRV CGYDTPFPHI FEPFYIPDKW KCYDALRKMI NY
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