Catechol O-methyltransferase (COMT)

About Catechol O-methyltransferase

Catechol O-methyltransferase (COMT) is a protein from Homo sapiens identified by UniProt accession P21964, 271 residues long. MolForge cross-references it against 0 known binders and 464 disease associations.

Target properties

Protein name	Catechol O-methyltransferase
UniProt accession	P21964
Gene	COMT
Organism	Homo sapiens
Length	271 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (7)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (464)

Diseases linked to this target (Open Targets).

Parkinson disease · score 0.61
response to tramadol · score 0.55
urinary metabolite measurement · score 0.44
schizophrenia · score 0.41
serum metabolite measurement · score 0.38
blood metabolite measurement · score 0.38
body mass index · score 0.38
sex hormone-binding globulin measurement · score 0.38
drug dependence · score 0.37
Hepatic failure · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P21964-F1	alphafold	PREDICTED	93.97	—

Amino-acid sequence (271 residues)

MPEAPPLLLA AVLLGLVLLV VLLLLLRHWG WGLCLIGWNE FILQPIHNLL MGDTKEQRIL NHVLQHAEPG NAQSVLEAID TYCEQKEWAM NVGDKKGKIV DAVIQEHQPS VLLELGAYCG YSAVRMARLL SPGARLITIE INPDCAAITQ RMVDFAGVKD KVTLVVGASQ DIIPQLKKKY DVDTLDMVFL DHWKDRYLPD TLLLEECGLL RKGTVLLADN VICPGAPDFL AHVRGSSCFE CTHYQSFLEY REVVDGLEKA IYKGPGSEAG P

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards