About Protein-glutamine gamma-glutamyltransferase 2
Protein-glutamine gamma-glutamyltransferase 2 (TGM2) is a protein
from Homo sapiens identified by UniProt accession
P21980, 687 residues long.
MolForge cross-references it against 0 known binders and
713 disease associations.
Target properties
| Protein name | Protein-glutamine gamma-glutamyltransferase 2 |
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| UniProt accession | P21980 |
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| Gene | TGM2 |
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| Organism | Homo sapiens |
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| Length | 687 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (713)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.49
- myeloid white cell count · score 0.33
- neuroinflammatory disorder · score 0.32
- leukocyte count · score 0.32
- protein measurement · score 0.32
- platelet count · score 0.25
- electrocardiography · score 0.23
- Parkinson disease · score 0.21
- multiple sclerosis · score 0.21
- lysosomal storage disease · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P21980-F1 | alphafold | PREDICTED | 92.87 | — |
Amino-acid sequence (687 residues)
MAEELVLERC DLELETNGRD HHTADLCREK LVVRRGQPFW LTLHFEGRNY EASVDSLTFS VVTGPAPSQE AGTKARFPLR DAVEEGDWTA TVVDQQDCTL SLQLTTPANA PIGLYRLSLE ASTGYQGSSF VLGHFILLFN AWCPADAVYL DSEEERQEYV LTQQGFIYQG SAKFIKNIPW NFGQFEDGIL DICLILLDVN PKFLKNAGRD CSRRSSPVYV GRVVSGMVNC NDDQGVLLGR WDNNYGDGVS PMSWIGSVDI LRRWKNHGCQ RVKYGQCWVF AAVACTVLRC LGIPTRVVTN YNSAHDQNSN LLIEYFRNEF GEIQGDKSEM IWNFHCWVES WMTRPDLQPG YEGWQALDPT PQEKSEGTYC CGPVPVRAIK EGDLSTKYDA PFVFAEVNAD VVDWIQQDDG SVHKSINRSL IVGLKISTKS VGRDEREDIT HTYKYPEGSS EEREAFTRAN HLNKLAEKEE TGMAMRIRVG QSMNMGSDFD VFAHITNNTA EEYVCRLLLC ARTVSYNGIL GPECGTKYLL NLNLEPFSEK SVPLCILYEK YRDCLTESNL IKVRALLVEP VINSYLLAER DLYLENPEIK IRILGEPKQK RKLVAEVSLQ NPLPVALEGC TFTVEGAGLT EEQKTVEIPD PVEAGEEVKV RMDLLPLHMG LHKLVVNFES DKLKAVKGFR NVIIGPA
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