About Potassium voltage-gated channel subfamily A member 3
Potassium voltage-gated channel subfamily A member 3 (KCNA3) is a protein
from Homo sapiens identified by UniProt accession
P22001, 575 residues long.
MolForge cross-references it against 0 known binders and
616 disease associations.
Target properties
| Protein name | Potassium voltage-gated channel subfamily A member 3 |
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| UniProt accession | P22001 |
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| Gene | KCNA3 |
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| Organism | Homo sapiens |
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| Length | 575 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (616)
Diseases linked to this target (Open Targets).
- multiple sclerosis · score 0.59
- Myasthenia gravis · score 0.57
- Muscle weakness · score 0.46
- small cell carcinoma · score 0.46
- secondary progressive multiple sclerosis · score 0.43
- transverse myelitis · score 0.37
- primary progressive multiple sclerosis · score 0.37
- anterior ischemic optic neuropathy · score 0.37
- atrial fibrillation · score 0.36
- atrial flutter · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P22001-F1 | alphafold | PREDICTED | 72.00 | — |
Amino-acid sequence (575 residues)
MDERLSLLRS PPPPSARHRA HPPQRPASSG GAHTLVNHGY AEPAAGRELP PDMTVVPGDH LLEPEVADGG GAPPQGGCGG GGCDRYEPLP PSLPAAGEQD CCGERVVINI SGLRFETQLK TLCQFPETLL GDPKRRMRYF DPLRNEYFFD RNRPSFDAIL YYYQSGGRIR RPVNVPIDIF SEEIRFYQLG EEAMEKFRED EGFLREEERP LPRRDFQRQV WLLFEYPESS GPARGIAIVS VLVILISIVI FCLETLPEFR DEKDYPASTS QDSFEAAGNS TSGSRAGASS FSDPFFVVET LCIIWFSFEL LVRFFACPSK ATFSRNIMNL IDIVAIIPYF ITLGTELAER QGNGQQAMSL AILRVIRLVR VFRIFKLSRH SKGLQILGQT LKASMRELGL LIFFLFIGVI LFSSAVYFAE ADDPTSGFSS IPDAFWWAVV TMTTVGYGDM HPVTIGGKIV GSLCAIAGVL TIALPVPVIV SNFNYFYHRE TEGEEQSQYM HVGSCQHLSS SAEELRKARS NSTLSKSEYM VIEEGGMNHS AFPQTPFKTG NSTATCTTNN NPNSCVNIKK IFTDV
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