Bone morphogenetic protein 5 (BMP5)

About Bone morphogenetic protein 5

Bone morphogenetic protein 5 (BMP5) is a protein from Homo sapiens identified by UniProt accession P22003, 454 residues long. MolForge cross-references it against 0 known binders and 657 disease associations.

Target properties

Protein name	Bone morphogenetic protein 5
UniProt accession	P22003
Gene	BMP5
Organism	Homo sapiens
Length	454 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (657)

Diseases linked to this target (Open Targets).

heel bone mineral density · score 0.52
bone quantitative ultrasound measurement · score 0.48
brain volume measurement · score 0.45
colorectal cancer · score 0.42
urate measurement · score 0.41
sitting height measurement · score 0.38
body height · score 0.38
bone density · score 0.36
osteoarthritis · score 0.34
cystatin C measurement · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P22003-F1	alphafold	PREDICTED	74.58	—

Amino-acid sequence (454 residues)

MHLTVFLLKG IVGFLWSCWV LVGYAKGGLG DNHVHSSFIY RRLRNHERRE IQREILSILG LPHRPRPFSP GKQASSAPLF MLDLYNAMTN EENPEESEYS VRASLAEETR GARKGYPASP NGYPRRIQLS RTTPLTTQSP PLASLHDTNF LNDADMVMSF VNLVERDKDF SHQRRHYKEF RFDLTQIPHG EAVTAAEFRI YKDRSNNRFE NETIKISIYQ IIKEYTNRDA DLFLLDTRKA QALDVGWLVF DITVTSNHWV INPQNNLGLQ LCAETGDGRS INVKSAGLVG RQGPQSKQPF MVAFFKASEV LLRSVRAANK RKNQNRNKSS SHQDSSRMSS VGDYNTSEQK QACKKHELYV SFRDLGWQDW IIAPEGYAAF YCDGECSFPL NAHMNATNHA IVQTLVHLMF PDHVPKPCCA PTKLNAISVL YFDDSSNVIL KKYRNMVVRS CGCH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards