Bone morphogenetic protein 6 (BMP6)

About Bone morphogenetic protein 6

Bone morphogenetic protein 6 (BMP6) is a protein from Homo sapiens identified by UniProt accession P22004, 513 residues long. MolForge cross-references it against 0 known binders and 291 disease associations.

Target properties

Protein name	Bone morphogenetic protein 6
UniProt accession	P22004
Gene	BMP6
Organism	Homo sapiens
Length	513 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (291)

Diseases linked to this target (Open Targets).

body height · score 0.52
lean body mass · score 0.49
appendicular lean mass · score 0.49
vital capacity · score 0.49
forced expiratory volume · score 0.46
sitting height measurement · score 0.45
BMI-adjusted hip circumference · score 0.44
pulse pressure measurement · score 0.44
platelet count · score 0.43
systolic blood pressure · score 0.43

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P22004-F1	alphafold	PREDICTED	68.91	—

Amino-acid sequence (513 residues)

MPGLGRRAQW LCWWWGLLCS CCGPPPLRPP LPAAAAAAAG GQLLGDGGSP GRTEQPPPSP QSSSGFLYRR LKTQEKREMQ KEILSVLGLP HRPRPLHGLQ QPQPPALRQQ EEQQQQQQLP RGEPPPGRLK SAPLFMLDLY NALSADNDED GASEGERQQS WPHEAASSSQ RRQPPPGAAH PLNRKSLLAP GSGSGGASPL TSAQDSAFLN DADMVMSFVN LVEYDKEFSP RQRHHKEFKF NLSQIPEGEV VTAAEFRIYK DCVMGSFKNQ TFLISIYQVL QEHQHRDSDL FLLDTRVVWA SEEGWLEFDI TATSNLWVVT PQHNMGLQLS VVTRDGVHVH PRAAGLVGRD GPYDKQPFMV AFFKVSEVHV RTTRSASSRR RQQSRNRSTQ SQDVARVSSA SDYNSSELKT ACRKHELYVS FQDLGWQDWI IAPKGYAANY CDGECSFPLN AHMNATNHAI VQTLVHLMNP EYVPKPCCAP TKLNAISVLY FDDNSNVILK KYRNMVVRAC GCH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards