About Methylmalonyl-CoA mutase, mitochondrial
Methylmalonyl-CoA mutase, mitochondrial (MMUT) is a protein
from Homo sapiens identified by UniProt accession
P22033, 750 residues long.
MolForge cross-references it against 0 known binders and
199 disease associations.
Target properties
| Protein name | Methylmalonyl-CoA mutase, mitochondrial |
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| UniProt accession | P22033 |
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| Gene | MMUT |
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| Organism | Homo sapiens |
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| Length | 750 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (199)
Diseases linked to this target (Open Targets).
- methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency · score 0.83
- vitamin B12-unresponsive methylmalonic acidemia type mut0 · score 0.63
- methylmalonic acidemia · score 0.57
- vitamin B12-unresponsive methylmalonic acidemia type mut- · score 0.55
- Abnormality of metabolism/homeostasis · score 0.45
- Vitamin B12-responsive methylmalonic acidemia type cblB · score 0.37
- aspartate aminotransferase measurement · score 0.31
- mean corpuscular volume · score 0.29
- Red cell distribution width · score 0.29
- acute infantile liver failure due to synthesis defect of mtDNA-encoded proteins · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P22033-F1 | alphafold | PREDICTED | 92.82 | — |
Amino-acid sequence (750 residues)
MLRAKNQLFL LSPHYLRQVK ESSGSRLIQQ RLLHQQQPLH PEWAALAKKQ LKGKNPEDLI WHTPEGISIK PLYSKRDTMD LPEELPGVKP FTRGPYPTMY TFRPWTIRQY AGFSTVEESN KFYKDNIKAG QQGLSVAFDL ATHRGYDSDN PRVRGDVGMA GVAIDTVEDT KILFDGIPLE KMSVSMTMNG AVIPVLANFI VTGEEQGVPK EKLTGTIQND ILKEFMVRNT YIFPPEPSMK IIADIFEYTA KHMPKFNSIS ISGYHMQEAG ADAILELAYT LADGLEYSRT GLQAGLTIDE FAPRLSFFWG IGMNFYMEIA KMRAGRRLWA HLIEKMFQPK NSKSLLLRAH CQTSGWSLTE QDPYNNIVRT AIEAMAAVFG GTQSLHTNSF DEALGLPTVK SARIARNTQI IIQEESGIPK VADPWGGSYM MECLTNDVYD AALKLINEIE EMGGMAKAVA EGIPKLRIEE CAARRQARID SGSEVIVGVN KYQLEKEDAV EVLAIDNTSV RNRQIEKLKK IKSSRDQALA ERCLAALTEC AASGDGNILA LAVDASRARC TVGEITDALK KVFGEHKAND RMVSGAYRQE FGESKEITSA IKRVHKFMER EGRRPRLLVA KMGQDGHDRG AKVIATGFAD LGFDVDIGPL FQTPREVAQQ AVDADVHAVG ISTLAAGHKT LVPELIKELN SLGRPDILVM CGGVIPPQDY EFLFEVGVSN VFGPGTRIPK AAVQVLDDIE KCLEKKQQSV
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