About Protein-L-isoaspartate(D-aspartate) O-methyltransferase
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) is a protein
from Homo sapiens identified by UniProt accession
P22061, 227 residues long.
MolForge cross-references it against 0 known binders and
108 disease associations.
Target properties
| Protein name | Protein-L-isoaspartate(D-aspartate) O-methyltransferase |
|---|
| UniProt accession | P22061 |
|---|
| Gene | PCMT1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 227 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (108)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- blood protein measurement · score 0.29
- serum metabolite measurement · score 0.21
- serum gamma-glutamyl transferase measurement · score 0.19
- refractive error measurement · score 0.18
- neuroimaging measurement · score 0.18
- brain measurement · score 0.17
- brain volume measurement · score 0.17
- C-reactive protein measurement · score 0.16
- cortical thickness · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P22061-F1 | alphafold | PREDICTED | 96.38 | — |
Amino-acid sequence (227 residues)
MAWKSGGASH SELIHNLRKN GIIKTDKVFE VMLATDRSHY AKCNPYMDSP QSIGFQATIS APHMHAYALE LLFDQLHEGA KALDVGSGSG ILTACFARMV GCTGKVIGID HIKELVDDSV NNVRKDDPTL LSSGRVQLVV GDGRMGYAEE APYDAIHVGA AAPVVPQALI DQLKPGGRLI LPVGPAGGNQ MLEQYDKLQD GSIKMKPLMG VIYVPLTDKE KQWSRWK
Explore Protein-L-isoaspartate(D-aspartate) O-methyltransferase with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets