Alpha-(1,3)-fucosyltransferase 4 (FUT4)

About Alpha-(1,3)-fucosyltransferase 4

Alpha-(1,3)-fucosyltransferase 4 (FUT4) is a protein from Homo sapiens identified by UniProt accession P22083, 530 residues long. MolForge cross-references it against 0 known binders and 521 disease associations.

Target properties

Protein name	Alpha-(1,3)-fucosyltransferase 4
UniProt accession	P22083
Gene	FUT4
Organism	Homo sapiens
Length	530 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (521)

Diseases linked to this target (Open Targets).

neoplasm · score 0.11
endometriosis · score 0.09
cancer · score 0.09
blood protein measurement · score 0.09
acute myeloid leukemia · score 0.08
melanoma · score 0.08
papillary thyroid carcinoma · score 0.08
lung adenocarcinoma · score 0.08
nonpapillary renal cell carcinoma · score 0.07
non-small cell lung carcinoma · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P22083-F1	alphafold	PREDICTED	73.08	—

Amino-acid sequence (530 residues)

MRRLWGAARK PSGAGWEKEW AEAPQEAPGA WSGRLGPGRS GRKGRAVPGW ASWPAHLALA ARPARHLGGA GQGPRPLHSG TAPFHSRASG ERQRRLEPQL QHESRCRSST PADAWRAEAA LPVRAMGAPW GSPTAAAGGR RGWRRGRGLP WTVCVLAAAG LTCTALITYA CWGQLPPLPW ASPTPSRPVG VLLWWEPFGG RDSAPRPPPD CRLRFNISGC RLLTDRASYG EAQAVLFHHR DLVKGPPDWP PPWGIQAHTA EEVDLRVLDY EEAAAAAEAL ATSSPRPPGQ RWVWMNFESP SHSPGLRSLA SNLFNWTLSY RADSDVFVPY GYLYPRSHPG DPPSGLAPPL SRKQGLVAWV VSHWDERQAR VRYYHQLSQH VTVDVFGRGG PGQPVPEIGL LHTVARYKFY LAFENSQHLD YITEKLWRNA LLAGAVPVVL GPDRANYERF VPRGAFIHVD DFPSASSLAS YLLFLDRNPA VYRRYFHWRR SYAVHITSFW DEPWCRVCQA VQRAGDRPKS IRNLASWFER

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards