About rRNA 2'-O-methyltransferase fibrillarin
rRNA 2'-O-methyltransferase fibrillarin (FBL) is a protein
from Homo sapiens identified by UniProt accession
P22087, 321 residues long.
MolForge cross-references it against 0 known binders and
251 disease associations.
Target properties
| Protein name | rRNA 2'-O-methyltransferase fibrillarin |
|---|
| UniProt accession | P22087 |
|---|
| Gene | FBL |
|---|
| Organism | Homo sapiens |
|---|
| Length | 321 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (251)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.47
- neoplasm · score 0.11
- hepatocellular carcinoma · score 0.10
- endometrial cancer · score 0.10
- infection · score 0.09
- infect · score 0.09
- Pallister-Hall syndrome · score 0.08
- type 2 diabetes mellitus · score 0.08
- esophageal squamous cell carcinoma · score 0.08
- diabetes mellitus · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P22087-F1 | alphafold | PREDICTED | 76.85 | — |
Amino-acid sequence (321 residues)
MKPGFSPRGG GFGGRGGFGD RGGRGGRGGF GGGRGRGGGF RGRGRGGGGG GGGGGGGGRG GGGFHSGGNR GRGRGGKRGN QSGKNVMVEP HRHEGVFICR GKEDALVTKN LVPGESVYGE KRVSISEGDD KIEYRAWNPF RSKLAAAILG GVDQIHIKPG AKVLYLGAAS GTTVSHVSDI VGPDGLVYAV EFSHRSGRDL INLAKKRTNI IPVIEDARHP HKYRMLIAMV DVIFADVAQP DQTRIVALNA HTFLRNGGHF VISIKANCID STASAEAVFA SEVKKMQQEN MKPQEQLTLE PYERDHAVVV GVYRPPPKVK N
Explore rRNA 2'-O-methyltransferase fibrillarin with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets