About Small ribosomal subunit protein eS4, Y isoform 1
Small ribosomal subunit protein eS4, Y isoform 1 (RPS4Y1) is a protein
from Homo sapiens identified by UniProt accession
P22090, 263 residues long.
MolForge cross-references it against 0 known binders and
65 disease associations.
Target properties
| Protein name | Small ribosomal subunit protein eS4, Y isoform 1 |
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| UniProt accession | P22090 |
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| Gene | RPS4Y1 |
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| Organism | Homo sapiens |
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| Length | 263 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (65)
Diseases linked to this target (Open Targets).
- Duchenne muscular dystrophy · score 0.50
- cystic fibrosis · score 0.50
- influenza · score 0.46
- COVID-19 · score 0.37
- severe acute respiratory syndrome · score 0.37
- Becker muscular dystrophy · score 0.29
- clear cell renal carcinoma · score 0.27
- qualitative or quantitative defects of dystrophin · score 0.26
- aniridia · score 0.09
- diffuse large B-cell lymphoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P22090-F1 | alphafold | PREDICTED | 95.43 | — |
Amino-acid sequence (263 residues)
MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIVFLRN RLKYALTGDE VKKICMQRFI KIDGKVRVDV TYPAGFMDVI SIEKTGEHFR LVYDTKGRFA VHRITVEEAK YKLCKVRKIT VGVKGIPHLV THDARTIRYP DPVIKVNDTV QIDLGTGKII NFIKFDTGNL CMVIGGANLG RVGVITNRER HPGSFDVVHV KDANGNSFAT RLSNIFVIGN GNKPWISLPR GKGIRLTVAE ERDKRLATKQ SSG
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