About Iduronate 2-sulfatase
Iduronate 2-sulfatase (IDS) is a protein
from Homo sapiens identified by UniProt accession
P22304, 550 residues long.
MolForge cross-references it against 0 known binders and
155 disease associations.
Target properties
| Protein name | Iduronate 2-sulfatase |
|---|
| UniProt accession | P22304 |
|---|
| Gene | IDS |
|---|
| Organism | Homo sapiens |
|---|
| Length | 550 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (155)
Diseases linked to this target (Open Targets).
- mucopolysaccharidosis type 2 · score 0.88
- genetic disorder · score 0.53
- mucopolysaccharidosis type 2, severe form · score 0.51
- mucopolysaccharidosis · score 0.47
- mucopolysaccharidosis type 3A · score 0.39
- mucopolysaccharidosis type 2, attenuated form · score 0.37
- Global developmental delay · score 0.12
- Macrocephaly · score 0.12
- Joint contracture of the hand · score 0.12
- Preauricular pit · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P22304-F1 | alphafold | PREDICTED | 93.08 | — |
Amino-acid sequence (550 residues)
MPPPRTGRGL LWLGLVLSSV CVALGSETQA NSTTDALNVL LIIVDDLRPS LGCYGDKLVR SPNIDQLASH SLLFQNAFAQ QAVCAPSRVS FLTGRRPDTT RLYDFNSYWR VHAGNFSTIP QYFKENGYVT MSVGKVFHPG ISSNHTDDSP YSWSFPPYHP SSEKYENTKT CRGPDGELHA NLLCPVDVLD VPEGTLPDKQ STEQAIQLLE KMKTSASPFF LAVGYHKPHI PFRYPKEFQK LYPLENITLA PDPEVPDGLP PVAYNPWMDI RQREDVQALN ISVPYGPIPV DFQRKIRQSY FASVSYLDTQ VGRLLSALDD LQLANSTIIA FTSDHGWALG EHGEWAKYSN FDVATHVPLI FYVPGRTASL PEAGEKLFPY LDPFDSASQL MEPGRQSMDL VELVSLFPTL AGLAGLQVPP RCPVPSFHVE LCREGKNLLK HFRFRDLEED PYLPGNPREL IAYSQYPRPS DIPQWNSDKP SLKDIKIMGY SIRTIDYRYT VWVGFNPDEF LANFSDIHAG ELYFVDSDPL QDHNMYNDSQ GGDLFQLLMP
Explore Iduronate 2-sulfatase with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets