About UDP-glucuronosyltransferase 1A1
UDP-glucuronosyltransferase 1A1 (UGT1A1) is a protein
from Homo sapiens identified by UniProt accession
P22309, 533 residues long.
MolForge cross-references it against 0 known binders and
74 disease associations.
Target properties
| Protein name | UDP-glucuronosyltransferase 1A1 |
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| UniProt accession | P22309 |
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| Gene | UGT1A1 |
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| Organism | Homo sapiens |
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| Length | 533 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (74)
Diseases linked to this target (Open Targets).
- Crigler-Najjar syndrome type 1 · score 0.84
- Crigler-Najjar syndrome type 2 · score 0.83
- Gilbert syndrome · score 0.81
- bilirubin measurement · score 0.70
- transient familial neonatal hyperbilirubinemia · score 0.70
- Crigler-Najjar syndrome · score 0.65
- porphyrin metabolism disease · score 0.59
- bilirubin metabolism disease · score 0.59
- Hyperbilirubinemia · score 0.52
- genetic disorder · score 0.49
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P22309-F1 | alphafold | PREDICTED | 91.00 | — |
Amino-acid sequence (533 residues)
MAVESQGGRP LVLGLLLCVL GPVVSHAGKI LLIPVDGSHW LSMLGAIQQL QQRGHEIVVL APDASLYIRD GAFYTLKTYP VPFQREDVKE SFVSLGHNVF ENDSFLQRVI KTYKKIKKDS AMLLSGCSHL LHNKELMASL AESSFDVMLT DPFLPCSPIV AQYLSLPTVF FLHALPCSLE FEATQCPNPF SYVPRPLSSH SDHMTFLQRV KNMLIAFSQN FLCDVVYSPY ATLASEFLQR EVTVQDLLSS ASVWLFRSDF VKDYPRPIMP NMVFVGGINC LHQNPLSQEF EAYINASGEH GIVVFSLGSM VSEIPEKKAM AIADALGKIP QTVLWRYTGT RPSNLANNTI LVKWLPQNDL LGHPMTRAFI THAGSHGVYE SICNGVPMVM MPLFGDQMDN AKRMETKGAG VTLNVLEMTS EDLENALKAV INDKSYKENI MRLSSLHKDR PVEPLDLAVF WVEFVMRHKG APHLRPAAHD LTWYQYHSLD VIGFLLAVVL TVAFITFKCC AYGYRKCLGK KGRVKKAHKS KTH
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