About UDP-glucuronosyltransferase 1A4
UDP-glucuronosyltransferase 1A4 (UGT1A4) is a protein
from Homo sapiens identified by UniProt accession
P22310, 534 residues long.
MolForge cross-references it against 0 known binders and
80 disease associations.
Target properties
| Protein name | UDP-glucuronosyltransferase 1A4 |
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| UniProt accession | P22310 |
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| Gene | UGT1A4 |
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| Organism | Homo sapiens |
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| Length | 534 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (80)
Diseases linked to this target (Open Targets).
- bilirubin measurement · score 0.69
- Crigler-Najjar syndrome · score 0.64
- Gilbert syndrome · score 0.59
- Crigler-Najjar syndrome type 1 · score 0.56
- Crigler-Najjar syndrome type 2 · score 0.55
- transient familial neonatal hyperbilirubinemia · score 0.52
- Hyperbilirubinemia · score 0.51
- genetic disorder · score 0.49
- trait in response to irinotecan · score 0.48
- porphyrin metabolism disease · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P22310-F1 | alphafold | PREDICTED | 90.89 | — |
Amino-acid sequence (534 residues)
MARGLQVPLP RLATGLLLLL SVQPWAESGK VLVVPTDGSP WLSMREALRE LHARGHQAVV LTPEVNMHIK EEKFFTLTAY AVPWTQKEFD RVTLGYTQGF FETEHLLKRY SRSMAIMNNV SLALHRCCVE LLHNEALIRH LNATSFDVVL TDPVNLCGAV LAKYLSIPAV FFWRYIPCDL DFKGTQCPNP SSYIPKLLTT NSDHMTFLQR VKNMLYPLAL SYICHTFSAP YASLASELFQ REVSVVDLVS YASVWLFRGD FVMDYPRPIM PNMVFIGGIN CANGKPLSQE FEAYINASGE HGIVVFSLGS MVSEIPEKKA MAIADALGKI PQTVLWRYTG TRPSNLANNT ILVKWLPQND LLGHPMTRAF ITHAGSHGVY ESICNGVPMV MMPLFGDQMD NAKRMETKGA GVTLNVLEMT SEDLENALKA VINDKSYKEN IMRLSSLHKD RPVEPLDLAV FWVEFVMRHK GAPHLRPAAH DLTWYQYHSL DVIGFLLAVV LTVAFITFKC CAYGYRKCLG KKGRVKKAHK SKTH
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