About Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1) is a protein
from Homo sapiens identified by UniProt accession
P22413, 925 residues long.
MolForge cross-references it against 0 known binders and
357 disease associations.
Target properties
| Protein name | Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 |
|---|
| UniProt accession | P22413 |
|---|
| Gene | ENPP1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 925 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (357)
Diseases linked to this target (Open Targets).
- arterial calcification, generalized, of infancy, 1 · score 0.83
- hypopigmentation-punctate palmoplantar keratoderma syndrome · score 0.78
- hypophosphatemic rickets, autosomal recessive, 2 · score 0.76
- Generalized arterial calcification of infancy · score 0.75
- type 2 diabetes mellitus · score 0.61
- phosphate measurement · score 0.58
- obesity · score 0.46
- autosomal recessive hypophosphatemic rickets · score 0.42
- Pseudoxanthoma elasticum · score 0.38
- ossification of the posterior longitudinal ligament of the spine · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P22413-F1 | alphafold | PREDICTED | 90.66 | — |
Amino-acid sequence (925 residues)
MERDGCAGGG SRGGEGGRAP REGPAGNGRD RGRSHAAEAP GDPQAAASLL APMDVGEEPL EKAARARTAK DPNTYKVLSL VLSVCVLTTI LGCIFGLKPS CAKEVKSCKG RCFERTFGNC RCDAACVELG NCCLDYQETC IEPEHIWTCN KFRCGEKRLT RSLCACSDDC KDKGDCCINY SSVCQGEKSW VEEPCESINE PQCPAGFETP PTLLFSLDGF RAEYLHTWGG LLPVISKLKK CGTYTKNMRP VYPTKTFPNH YSIVTGLYPE SHGIIDNKMY DPKMNASFSL KSKEKFNPEW YKGEPIWVTA KYQGLKSGTF FWPGSDVEIN GIFPDIYKMY NGSVPFEERI LAVLQWLQLP KDERPHFYTL YLEEPDSSGH SYGPVSSEVI KALQRVDGMV GMLMDGLKEL NLHRCLNLIL ISDHGMEQGS CKKYIYLNKY LGDVKNIKVI YGPAARLRPS DVPDKYYSFN YEGIARNLSC REPNQHFKPY LKHFLPKRLH FAKSDRIEPL TFYLDPQWQL ALNPSERKYC GSGFHGSDNV FSNMQALFVG YGPGFKHGIE ADTFENIEVY NLMCDLLNLT PAPNNGTHGS LNHLLKNPVY TPKHPKEVHP LVQCPFTRNP RDNLGCSCNP SILPIEDFQT QFNLTVAEEK IIKHETLPYG RPRVLQKENT ICLLSQHQFM SGYSQDILMP LWTSYTVDRN DSFSTEDFSN CLYQDFRIPL SPVHKCSFYK NNTKVSYGFL SPPQLNKNSS GIYSEALLTT NIVPMYQSFQ VIWRYFHDTL LRKYAEERNG VNVVSGPVFD FDYDGRCDSL ENLRQKRRVI RNQEILIPTH FFIVLTSCKD TSQTPLHCEN LDTLAFILPH RTDNSESCVH GKHDSSWVEE LLMLHRARIT DVEHITGLSF YQQRKEPVSD ILKLKTHLPT FSQED
Explore Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets