Upstream stimulatory factor 1 (USF1)

About Upstream stimulatory factor 1

Upstream stimulatory factor 1 (USF1) is a protein from Homo sapiens identified by UniProt accession P22415, 310 residues long. MolForge cross-references it against 0 known binders and 133 disease associations.

Target properties

Protein name	Upstream stimulatory factor 1
UniProt accession	P22415
Gene	USF1
Organism	Homo sapiens
Length	310 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (133)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.44
monocyte count · score 0.18
leukocyte count · score 0.13
granulocyte percentage of myeloid white cells · score 0.12
monocyte percentage of leukocytes · score 0.11
hepatocellular carcinoma · score 0.09
lung adenocarcinoma · score 0.08
cardiovascular disease · score 0.08
atherosclerosis · score 0.06
coronary artery disease · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P22415-F1	alphafold	PREDICTED	60.93	—

Amino-acid sequence (310 residues)

MKGQQKTAET EEGTVQIQEG AVATGEDPTS VAIASIQSAA TFPDPNVKYV FRTENGGQVM YRVIQVSEGQ LDGQTEGTGA ISGYPATQSM TQAVIQGAFT SDDAVDTEGT AAETHYTYFP STAVGDGAGG TTSGSTAAVV TTQGSEALLG QATPPGTGQF FVMMSPQEVL QGGSQRSIAP RTHPYSPKSE APRTTRDEKR RAQHNEVERR RRDKINNWIV QLSKIIPDCS MESTKSGQSK GGILSKACDY IQELRQSNHR LSEELQGLDQ LQLDNDVLRQ QVEDLKNKNL LLRAQLRHHG LEVVIKNDSN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards