About Histone H1t
Histone H1t (H1-6) is a protein
from Homo sapiens identified by UniProt accession
P22492, 207 residues long.
MolForge cross-references it against 0 known binders and
84 disease associations.
Target properties
| Protein name | Histone H1t |
|---|
| UniProt accession | P22492 |
|---|
| Gene | H1-6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 207 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (84)
Diseases linked to this target (Open Targets).
- type 1 diabetes mellitus · score 0.30
- diabetic retinopathy · score 0.30
- iron metabolism disease · score 0.28
- pulse pressure measurement · score 0.26
- platelet count · score 0.24
- proliferative diabetic retinopathy · score 0.23
- diabetes mellitus · score 0.22
- complication · score 0.21
- refractive error · score 0.16
- mean corpuscular volume · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P22492-F1 | alphafold | PREDICTED | 63.77 | — |
Amino-acid sequence (207 residues)
MSETVPAASA SAGVAAMEKL PTKKRGRKPA GLISASRKVP NLSVSKLITE ALSVSQERVG MSLVALKKAL AAAGYDVEKN NSRIKLSLKS LVNKGILVQT RGTGASGSFK LSKKVIPKST RSKAKKSVSA KTKKLVLSRD SKSPKTAKTN KRAKKPRATT PKTVRSGRKA KGAKGKQQQK SPVKARASKS KLTQHHEVNV RKATSKK
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