About 5-aminolevulinate synthase, erythroid-specific, mitochondrial
5-aminolevulinate synthase, erythroid-specific, mitochondrial (ALAS2) is a protein
from Homo sapiens identified by UniProt accession
P22557, 587 residues long.
MolForge cross-references it against 0 known binders and
172 disease associations.
Target properties
| Protein name | 5-aminolevulinate synthase, erythroid-specific, mitochondrial |
|---|
| UniProt accession | P22557 |
|---|
| Gene | ALAS2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 587 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (172)
Diseases linked to this target (Open Targets).
- X-linked sideroblastic anemia 1 · score 0.82
- X-linked erythropoietic protoporphyria · score 0.76
- mean corpuscular hemoglobin · score 0.50
- mean corpuscular volume · score 0.46
- Erythema · score 0.27
- Red cell distribution width · score 0.22
- hematological measurement · score 0.20
- genetic disorder · score 0.19
- erythrocyte count · score 0.16
- mean reticulocyte volume · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P22557-F1 | alphafold | PREDICTED | 82.22 | — |
Amino-acid sequence (587 residues)
MVTAAMLLQC CPVLARGPTS LLGKVVKTHQ FLFGIGRCPI LATQGPNCSQ IHLKATKAGG DSPSWAKGHC PFMLSELQDG KSKIVQKAAP EVQEDVKAFK TDLPSSLVSV SLRKPFSGPQ EQEQISGKVT HLIQNNMPGN YVFSYDQFFR DKIMEKKQDH TYRVFKTVNR WADAYPFAQH FSEASVASKD VSVWCSNDYL GMSRHPQVLQ ATQETLQRHG AGAGGTRNIS GTSKFHVELE QELAELHQKD SALLFSSCFV ANDSTLFTLA KILPGCEIYS DAGNHASMIQ GIRNSGAAKF VFRHNDPDHL KKLLEKSNPK IPKIVAFETV HSMDGAICPL EELCDVSHQY GALTFVDEVH AVGLYGSRGA GIGERDGIMH KIDIISGTLG KAFGCVGGYI ASTRDLVDMV RSYAAGFIFT TSLPPMVLSG ALESVRLLKG EEGQALRRAH QRNVKHMRQL LMDRGLPVIP CPSHIIPIRV GNAALNSKLC DLLLSKHGIY VQAINYPTVP RGEELLRLAP SPHHSPQMME DFVEKLLLAW TAVGLPLQDV SVAACNFCRR PVHFELMSEW ERSYFGNMGP QYVTTYA
Explore 5-aminolevulinate synthase, erythroid-specific, mitochondrial with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets