About NADPH:adrenodoxin oxidoreductase, mitochondrial
NADPH:adrenodoxin oxidoreductase, mitochondrial (FDXR) is a protein
from Homo sapiens identified by UniProt accession
P22570, 491 residues long.
MolForge cross-references it against 0 known binders and
95 disease associations.
Target properties
| Protein name | NADPH:adrenodoxin oxidoreductase, mitochondrial |
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| UniProt accession | P22570 |
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| Gene | FDXR |
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| Organism | Homo sapiens |
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| Length | 491 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (95)
Diseases linked to this target (Open Targets).
- auditory neuropathy-optic atrophy syndrome · score 0.75
- genetic disorder · score 0.52
- optic atrophy-ataxia-peripheral neuropathy-global developmental delay syndrome · score 0.49
- congenital adrenal hyperplasia · score 0.37
- auditory neuropathy · score 0.27
- head and neck squamous cell carcinoma · score 0.16
- squamous cell lung carcinoma · score 0.16
- urate measurement · score 0.14
- bone density · score 0.14
- urinary bladder cancer · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P22570-F1 | alphafold | PREDICTED | 92.10 | — |
Amino-acid sequence (491 residues)
MASRCWRWWG WSAWPRTRLP PAGSTPSFCH HFSTQEKTPQ ICVVGSGPAG FYTAQHLLKH PQAHVDIYEK QPVPFGLVRF GVAPDHPEVK NVINTFTQTA HSGRCAFWGN VEVGRDVTVP ELREAYHAVV LSYGAEDHRA LEIPGEELPG VCSARAFVGW YNGLPENQEL EPDLSCDTAV ILGQGNVALD VARILLTPPE HLERTDITKA ALGVLRQSRV KTVWLVGRRG PLQVAFTIKE LREMIQLPGA RPILDPVDFL GLQDKIKEVP RPRKRLTELL LRTATEKPGP AEAARQASAS RAWGLRFFRS PQQVLPSPDG RRAAGVRLAV TRLEGVDEAT RAVPTGDMED LPCGLVLSSI GYKSRPVDPS VPFDSKLGVI PNVEGRVMDV PGLYCSGWVK RGPTGVIATT MTDSFLTGQM LLQDLKAGLL PSGPRPGYAA IQALLSSRGV RPVSFSDWEK LDAEEVARGQ GTGKPREKLV DPQEMLRLLG H
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