About cAMP-dependent protein kinase catalytic subunit gamma
cAMP-dependent protein kinase catalytic subunit gamma (PRKACG) is a protein
from Homo sapiens identified by UniProt accession
P22612, 351 residues long.
MolForge cross-references it against 0 known binders and
37 disease associations.
Target properties
| Protein name | cAMP-dependent protein kinase catalytic subunit gamma |
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| UniProt accession | P22612 |
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| Gene | PRKACG |
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| Organism | Homo sapiens |
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| Length | 351 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (37)
Diseases linked to this target (Open Targets).
- platelet-type bleeding disorder 19 · score 0.50
- Rare hemorrhagic disorder due to a constitutional platelet anomaly · score 0.37
- breast adenocarcinoma · score 0.26
- endometrial cancer · score 0.25
- neurodegenerative disease · score 0.24
- cutaneous melanoma · score 0.20
- ovarian cancer · score 0.18
- esophageal cancer · score 0.18
- platelet component distribution width · score 0.11
- head and neck squamous cell carcinoma · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P22612-F1 | alphafold | PREDICTED | 94.65 | — |
Amino-acid sequence (351 residues)
MGNAPAKKDT EQEESVNEFL AKARGDFLYR WGNPAQNTAS SDQFERLRTL GMGSFGRVML VRHQETGGHY AMKILNKQKV VKMKQVEHIL NEKRILQAID FPFLVKLQFS FKDNSYLYLV MEYVPGGEMF SRLQRVGRFS EPHACFYAAQ VVLAVQYLHS LDLIHRDLKP ENLLIDQQGY LQVTDFGFAK RVKGRTWTLC GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAVGFPPFY ADQPIQIYEK IVSGRVRFPS KLSSDLKHLL RSLLQVDLTK RFGNLRNGVG DIKNHKWFAT TSWIAIYEKK VEAPFIPKYT GPGDASNFDD YEEEELRISI NEKCAKEFSE F
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