About Cyclin-O
Cyclin-O (CCNO) is a protein
from Homo sapiens identified by UniProt accession
P22674, 350 residues long.
MolForge cross-references it against 0 known binders and
75 disease associations.
Target properties
| Protein name | Cyclin-O |
|---|
| UniProt accession | P22674 |
|---|
| Gene | CCNO |
|---|
| Organism | Homo sapiens |
|---|
| Length | 350 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (75)
Diseases linked to this target (Open Targets).
- primary ciliary dyskinesia · score 0.70
- genetic disorder · score 0.19
- eosinophil count · score 0.10
- eosinophil percentage of leukocytes · score 0.09
- lung adenocarcinoma · score 0.08
- Hydrocephalus · score 0.08
- gonorrhea · score 0.07
- neoplasm · score 0.06
- bone quantitative ultrasound measurement · score 0.04
- bone density · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P22674-F1 | alphafold | PREDICTED | 78.41 | — |
Amino-acid sequence (350 residues)
MVTPCPTSPS SPAARAGRRD NDQNLRAPVK KSRRPRLRRK QPLHPLNPCP LPGDSGICDL FESPSSGSDG AESPSAARGG SPLPGPAQPV AQLDLQTFRD YGQSCYAFRK AQESHFHPRE ALARQPQVTA ESRCKLLSWL IPVHRQFGLS FESLCLTVNT LDRFLTTTPV AADCFQLLGV TSLLIACKQV EVHPPRVKQL LALCCGAFSR QQLCNLECIV LHKLHFTLGA PTISFFLEHF THARVEAGQA EASEALEAQA LARGVAELSL ADYAFTSYSP SLLAICCLAL ADRMLRVSRP VDLRLGDHPE AALEDCMGKL QLLVAINSTS LTHMLPVQIC EKCSLPPSSK
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