About Cytochrome P450 7A1
Cytochrome P450 7A1 (CYP7A1) is a protein
from Homo sapiens identified by UniProt accession
P22680, 504 residues long.
MolForge cross-references it against 0 known binders and
217 disease associations.
Target properties
| Protein name | Cytochrome P450 7A1 |
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| UniProt accession | P22680 |
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| Gene | CYP7A1 |
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| Organism | Homo sapiens |
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| Length | 504 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (217)
Diseases linked to this target (Open Targets).
- low density lipoprotein cholesterol measurement · score 0.44
- cholelithiasis · score 0.43
- total cholesterol measurement · score 0.43
- sex hormone-binding globulin measurement · score 0.42
- triglyceride measurement · score 0.38
- serum gamma-glutamyl transferase measurement · score 0.38
- hypercholesterolemia due to cholesterol 7alpha-hydroxylase deficiency · score 0.37
- apolipoprotein B measurement · score 0.36
- IGF-1 measurement · score 0.34
- HMG CoA reductase inhibitor use measurement · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P22680-F1 | alphafold | PREDICTED | 94.81 | — |
Amino-acid sequence (504 residues)
MMTTSLIWGI AIAACCCLWL ILGIRRRQTG EPPLENGLIP YLGCALQFGA NPLEFLRANQ RKHGHVFTCK LMGKYVHFIT NPLSYHKVLC HGKYFDWKKF HFATSAKAFG HRSIDPMDGN TTENINDTFI KTLQGHALNS LTESMMENLQ RIMRPPVSSN SKTAAWVTEG MYSFCYRVMF EAGYLTIFGR DLTRRDTQKA HILNNLDNFK QFDKVFPALV AGLPIHMFRT AHNAREKLAE SLRHENLQKR ESISELISLR MFLNDTLSTF DDLEKAKTHL VVLWASQANT IPATFWSLFQ MIRNPEAMKA ATEEVKRTLE NAGQKVSLEG NPICLSQAEL NDLPVLDSII KESLRLSSAS LNIRTAKEDF TLHLEDGSYN IRKDDIIALY PQLMHLDPEI YPDPLTFKYD RYLDENGKTK TTFYCNGLKL KYYYMPFGSG ATICPGRLFA IHEIKQFLIL MLSYFELELI EGQAKCPPLD QSRAGLGILP PLNDIEFKYK FKHL
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