About Insulin-like growth factor-binding protein 4
Insulin-like growth factor-binding protein 4 (IGFBP4) is a protein
from Homo sapiens identified by UniProt accession
P22692, 258 residues long.
MolForge cross-references it against 0 known binders and
231 disease associations.
Target properties
| Protein name | Insulin-like growth factor-binding protein 4 |
|---|
| UniProt accession | P22692 |
|---|
| Gene | IGFBP4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 258 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (231)
Diseases linked to this target (Open Targets).
- body height · score 0.34
- lean body mass · score 0.32
- leukocyte count · score 0.28
- fat body mass · score 0.27
- Abnormal brain morphology · score 0.27
- sitting height measurement · score 0.23
- base metabolic rate measurement · score 0.23
- anthropometric measurement · score 0.23
- whole body water mass · score 0.22
- cutaneous melanoma · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P22692-F1 | alphafold | PREDICTED | 77.26 | — |
Amino-acid sequence (258 residues)
MLPLCLVAAL LLAAGPGPSL GDEAIHCPPC SEEKLARCRP PVGCEELVRE PGCGCCATCA LGLGMPCGVY TPRCGSGLRC YPPRGVEKPL HTLMHGQGVC MELAEIEAIQ ESLQPSDKDE GDHPNNSFSP CSAHDRRCLQ KHFAKIRDRS TSGGKMKVNG APREDARPVP QGSCQSELHR ALERLAASQS RTHEDLYIIP IPNCDRNGNF HPKQCHPALD GQRGKCWCVD RKTGVKLPGG LEPKGELDCH QLADSFRE
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