About Solute carrier family 2, facilitated glucose transporter member 5
Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5) is a protein
from Homo sapiens identified by UniProt accession
P22732, 501 residues long.
MolForge cross-references it against 0 known binders and
247 disease associations.
Target properties
| Protein name | Solute carrier family 2, facilitated glucose transporter member 5 |
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| UniProt accession | P22732 |
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| Gene | SLC2A5 |
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| Organism | Homo sapiens |
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| Length | 501 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (247)
Diseases linked to this target (Open Targets).
- Prolonged QT interval · score 0.33
- neurodegenerative disease · score 0.22
- neurofibrillary tangles measurement · score 0.22
- leukocyte count · score 0.12
- monocyte percentage of leukocytes · score 0.11
- aspartate aminotransferase measurement · score 0.11
- lung adenocarcinoma · score 0.10
- neoplasm · score 0.10
- monocyte count · score 0.10
- cancer · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P22732-F1 | alphafold | PREDICTED | 90.56 | — |
Amino-acid sequence (501 residues)
MEQQDQSMKE GRLTLVLALA TLIAAFGSSF QYGYNVAAVN SPALLMQQFY NETYYGRTGE FMEDFPLTLL WSVTVSMFPF GGFIGSLLVG PLVNKFGRKG ALLFNNIFSI VPAILMGCSR VATSFELIII SRLLVGICAG VSSNVVPMYL GELAPKNLRG ALGVVPQLFI TVGILVAQIF GLRNLLANVD GWPILLGLTG VPAALQLLLL PFFPESPRYL LIQKKDEAAA KKALQTLRGW DSVDREVAEI RQEDEAEKAA GFISVLKLFR MRSLRWQLLS IIVLMGGQQL SGVNAIYYYA DQIYLSAGVP EEHVQYVTAG TGAVNVVMTF CAVFVVELLG RRLLLLLGFS ICLIACCVLT AALALQDTVS WMPYISIVCV ISYVIGHALG PSPIPALLIT EIFLQSSRPS AFMVGGSVHW LSNFTVGLIF PFIQEGLGPY SFIVFAVICL LTTIYIFLIV PETKAKTFIE INQIFTKMNK VSEVYPEKEE LKELPPVTSE Q
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