About Protein-glutamine gamma-glutamyltransferase K
Protein-glutamine gamma-glutamyltransferase K (TGM1) is a protein
from Homo sapiens identified by UniProt accession
P22735, 817 residues long.
MolForge cross-references it against 0 known binders and
174 disease associations.
Target properties
| Protein name | Protein-glutamine gamma-glutamyltransferase K |
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| UniProt accession | P22735 |
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| Gene | TGM1 |
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| Organism | Homo sapiens |
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| Length | 817 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (174)
Diseases linked to this target (Open Targets).
- autosomal recessive congenital ichthyosis · score 0.69
- lamellar ichthyosis · score 0.65
- Abnormality of the skin · score 0.48
- congenital reticular ichthyosiform erythroderma · score 0.41
- acral self-healing collodion baby · score 0.38
- congenital non-bullous ichthyosiform erythroderma · score 0.37
- bathing suit ichthyosis · score 0.37
- self-healing collodion baby · score 0.37
- ichthyosis · score 0.34
- red blood cell density measurement · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P22735-F1 | alphafold | PREDICTED | 84.14 | — |
Amino-acid sequence (817 residues)
MMDGPRSDVG RWGGNPLQPP TTPSPEPEPE PDGRSRRGGG RSFWARCCGC CSCRNAADDD WGPEPSDSRG RGSSSGTRRP GSRGSDSRRP VSRGSGVNAA GDGTIREGML VVNGVDLLSS RSDQNRREHH TDEYEYDELI VRRGQPFHML LLLSRTYESS DRITLELLIG NNPEVGKGTH VIIPVGKGGS GGWKAQVVKA SGQNLNLRVH TSPNAIIGKF QFTVRTQSDA GEFQLPFDPR NEIYILFNPW CPEDIVYVDH EDWRQEYVLN ESGRIYYGTE AQIGERTWNY GQFDHGVLDA CLYILDRRGM PYGGRGDPVN VSRVISAMVN SLDDNGVLIG NWSGDYSRGT NPSAWVGSVE ILLSYLRTGY SVPYGQCWVF AGVTTTVLRC LGLATRTVTN FNSAHDTDTS LTMDIYFDEN MKPLEHLNHD SVWNFHVWND CWMKRPDLPS GFDGWQVVDA TPQETSSGIF CCGPCSVESI KNGLVYMKYD TPFIFAEVNS DKVYWQRQDD GSFKIVYVEE KAIGTLIVTK AISSNMREDI TYLYKHPEGS DAERKAVETA AAHGSKPNVY ANRGSAEDVA MQVEAQDAVM GQDLMVSVML INHSSSRRTV KLHLYLSVTF YTGVSGTIFK ETKKEVELAP GASDRVTMPV AYKEYRPHLV DQGAMLLNVS GHVKESGQVL AKQHTFRLRT PDLSLTLLGA AVVGQECEVQ IVFKNPLPVT LTNVVFRLEG SGLQRPKILN VGDIGGNETV TLRQSFVPVR PGPRQLIASL DSPQLSQVHG VIQVDVAPAP GDGGFFSDAG GDSHLGETIP MASRGGA
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