Granulysin (GNLY)

About Granulysin

Granulysin (GNLY) is a protein from Homo sapiens identified by UniProt accession P22749, 145 residues long. MolForge cross-references it against 0 known binders and 221 disease associations.

Target properties

Protein name	Granulysin
UniProt accession	P22749
Gene	GNLY
Organism	Homo sapiens
Length	145 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (221)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.41
granulysin measurement · score 0.31
protein measurement · score 0.22
endometrial cancer · score 0.15
head and neck squamous cell carcinoma · score 0.13
cataract · score 0.12
breast adenocarcinoma · score 0.10
Vitiligo · score 0.09
halo nevus · score 0.08
pulmonary tuberculosis · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P22749-F1	alphafold	PREDICTED	78.07	—

Amino-acid sequence (145 residues)

MATWALLLLA AMLLGNPGLV FSRLSPEYYD LARAHLRDEE KSCPCLAQEG PQGDLLTKTQ ELGRDYRTCL TIVQKLKKMV DKPTQRSVSN AATRVCRTGR SRWRDVCRNF MRRYQSRVTQ GLVAGETAQQ ICEDLRLCIP STGPL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards