About Ferrochelatase, mitochondrial
Ferrochelatase, mitochondrial (FECH) is a protein
from Homo sapiens identified by UniProt accession
P22830, 423 residues long.
MolForge cross-references it against 0 known binders and
395 disease associations.
Target properties
| Protein name | Ferrochelatase, mitochondrial |
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| UniProt accession | P22830 |
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| Gene | FECH |
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| Organism | Homo sapiens |
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| Length | 423 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (12)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (395)
Diseases linked to this target (Open Targets).
- autosomal erythropoietic protoporphyria · score 0.77
- neurodegenerative disease · score 0.55
- erythropoietic protoporphyria · score 0.47
- Red cell distribution width · score 0.45
- mean corpuscular volume · score 0.43
- mean corpuscular hemoglobin · score 0.41
- mean corpuscular hemoglobin concentration · score 0.39
- Alzheimer disease · score 0.37
- Increased erythrocyte protoporphyrin concentration · score 0.34
- lysosomal storage disease · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P22830-F1 | alphafold | PREDICTED | 86.59 | — |
Amino-acid sequence (423 residues)
MRSLGANMAA ALRAAGVLLR DPLASSSWRV CQPWRWKSGA AAAAVTTETA QHAQGAKPQV QPQKRKPKTG ILMLNMGGPE TLGDVHDFLL RLFLDRDLMT LPIQNKLAPF IAKRRTPKIQ EQYRRIGGGS PIKIWTSKQG EGMVKLLDEL SPNTAPHKYY IGFRYVHPLT EEAIEEMERD GLERAIAFTQ YPQYSCSTTG SSLNAIYRYY NQVGRKPTMK WSTIDRWPTH HLLIQCFADH ILKELDHFPL EKRSEVVILF SAHSLPMSVV NRGDPYPQEV SATVQKVMER LEYCNPYRLV WQSKVGPMPW LGPQTDESIK GLCERGRKNI LLVPIAFTSD HIETLYELDI EYSQVLAKEC GVENIRRAES LNGNPLFSKA LADLVHSHIQ SNELCSKQLT LSCPLCVNPV CRETKSFFTS QQL
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