Vitamin K-dependent protein Z (PROZ)

About Vitamin K-dependent protein Z

Vitamin K-dependent protein Z (PROZ) is a protein from Homo sapiens identified by UniProt accession P22891, 400 residues long. MolForge cross-references it against 0 known binders and 82 disease associations.

Target properties

Protein name	Vitamin K-dependent protein Z
UniProt accession	P22891
Gene	PROZ
Organism	Homo sapiens
Length	400 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (82)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.42
coagulation factor measurement · score 0.35
mean platelet volume · score 0.31
protein Z deficiency · score 0.28
reticulocyte measurement · score 0.25
cutaneous melanoma · score 0.20
mean corpuscular volume · score 0.19
mean corpuscular hemoglobin · score 0.18
endometrial cancer · score 0.14
Immature Reticulocyte Fraction Measurement · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P22891-F1	alphafold	PREDICTED	85.16	—

Amino-acid sequence (400 residues)

MAGCVPLLQG LVLVLALHRV EPSVFLPASK ANDVLVRWKR AGSYLLEELF EGNLEKECYE EICVYEEARE VFENEVVTDE FWRRYKGGSP CISQPCLHNG SCQDSIWGYT CTCSPGYEGS NCELAKNECH PERTDGCQHF CLPGQESYTC SCAQGYRLGE DHKQCVPHDQ CACGVLTSEK RAPDLQDLPW QVKLTNSEGK DFCGGVIIRE NFVLTTAKCS LLHRNITVKT YFNRTSQDPL MIKITHVHVH MRYDADAGEN DLSLLELEWP IQCPGAGLPV CTPEKDFAEH LLIPRTRGLL SGWARNGTDL GNSLTTRPVT LVEGEECGQV LNVTVTTRTY CERSSVAAMH WMDGSVVTRE HRGSWFLTGV LGSQPVGGQA HMVLVTKVSR YSLWFKQIMN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards