Neutrophil collagenase (MMP8)

About Neutrophil collagenase

Neutrophil collagenase (MMP8) is a protein from Homo sapiens identified by UniProt accession P22894, 467 residues long. MolForge cross-references it against 0 known binders and 612 disease associations.

Target properties

Protein name	Neutrophil collagenase
UniProt accession	P22894
Gene	MMP8
Organism	Homo sapiens
Length	467 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (3)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (612)

Diseases linked to this target (Open Targets).

acne · score 0.61
periodontitis · score 0.60
rosacea · score 0.59
Helicobacter pylori infectious disease · score 0.59
infection · score 0.59
COVID-19 · score 0.58
chronic obstructive pulmonary disease · score 0.58
Lyme disease · score 0.57
Borrelia infectious disease · score 0.56
Chlamydia trachomatis infectious disease · score 0.55

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P22894-F1	alphafold	PREDICTED	90.37	—

Amino-acid sequence (467 residues)

MFSLKTLPFL LLLHVQISKA FPVSSKEKNT KTVQDYLEKF YQLPSNQYQS TRKNGTNVIV EKLKEMQRFF GLNVTGKPNE ETLDMMKKPR CGVPDSGGFM LTPGNPKWER TNLTYRIRNY TPQLSEAEVE RAIKDAFELW SVASPLIFTR ISQGEADINI AFYQRDHGDN SPFDGPNGIL AHAFQPGQGI GGDAHFDAEE TWTNTSANYN LFLVAAHEFG HSLGLAHSSD PGALMYPNYA FRETSNYSLP QDDIDGIQAI YGLSSNPIQP TGPSTPKPCD PSLTFDAITT LRGEILFFKD RYFWRRHPQL QRVEMNFISL FWPSLPTGIQ AAYEDFDRDL IFLFKGNQYW ALSGYDILQG YPKDISNYGF PSSVQAIDAA VFYRSKTYFF VNDQFWRYDN QRQFMEPGYP KSISGAFPGI ESKVDAVFQQ EHFFHVFSGP RYYAFDLIAQ RVTRVARGNK WLNCRYG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards