About Gamma-crystallin S
Gamma-crystallin S (CRYGS) is a protein
from Homo sapiens identified by UniProt accession
P22914, 178 residues long.
MolForge cross-references it against 0 known binders and
152 disease associations.
Target properties
| Protein name | Gamma-crystallin S |
|---|
| UniProt accession | P22914 |
|---|
| Gene | CRYGS |
|---|
| Organism | Homo sapiens |
|---|
| Length | 178 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (152)
Diseases linked to this target (Open Targets).
- Total congenital cataract · score 0.71
- early-onset non-syndromic cataract · score 0.54
- Cataract with Y-shaped suture opacities · score 0.52
- cataract · score 0.52
- early-onset sutural cataract · score 0.37
- retinitis pigmentosa · score 0.35
- Developmental cataract · score 0.33
- leukocyte count · score 0.31
- systolic blood pressure · score 0.25
- open-angle glaucoma · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P22914-F1 | alphafold | PREDICTED | 95.32 | — |
Amino-acid sequence (178 residues)
MSKTGTKITF YEDKNFQGRR YDCDCDCADF HTYLSRCNSI KVEGGTWAVY ERPNFAGYMY ILPQGEYPEY QRWMGLNDRL SSCRAVHLPS GGQYKIQIFE KGDFSGQMYE TTEDCPSIME QFHMREIHSC KVLEGVWIFY ELPNYRGRQY LLDKKEYRKP IDWGAASPAV QSFRRIVE
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