DNA repair protein complementing XP-A cells (XPA)

About DNA repair protein complementing XP-A cells

DNA repair protein complementing XP-A cells (XPA) is a protein from Homo sapiens identified by UniProt accession P23025, 273 residues long. MolForge cross-references it against 0 known binders and 301 disease associations.

Target properties

Protein name	DNA repair protein complementing XP-A cells
UniProt accession	P23025
Gene	XPA
Organism	Homo sapiens
Length	273 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (301)

Diseases linked to this target (Open Targets).

xeroderma pigmentosum group A · score 0.82
xeroderma pigmentosum · score 0.67
Xeroderma pigmentosum complementation group A · score 0.60
genetic disorder · score 0.46
basal cell carcinoma · score 0.46
non-melanoma skin carcinoma · score 0.46
skin cancer · score 0.46
neurodegenerative disease · score 0.39
colorectal adenocarcinoma · score 0.37
Endometrial Endometrioid Adenocarcinoma · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P23025-F1	alphafold	PREDICTED	81.37	—

Amino-acid sequence (273 residues)

MAAADGALPE AAALEQPAEL PASVRASIER KRQRALMLRQ ARLAARPYSA TAAAATGGMA NVKAAPKIID TGGGFILEEE EEEEQKIGKV VHQPGPVMEF DYVICEECGK EFMDSYLMNH FDLPTCDNCR DADDKHKLIT KTEAKQEYLL KDCDLEKREP PLKFIVKKNP HHSQWGDMKL YLKLQIVKRS LEVWGSQEAL EEAKEVRQEN REKMKQKKFD KKVKELRRAV RSSVWKRETI VHQHEYGPEE NLEDDMYRKT CTMCGHELTY EKM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards