Immunoglobulin heavy variable 1-2 (IGHV1-2)

About Immunoglobulin heavy variable 1-2

Immunoglobulin heavy variable 1-2 (IGHV1-2) is a protein from Homo sapiens identified by UniProt accession P23083, 117 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.

Target properties

Protein name	Immunoglobulin heavy variable 1-2
UniProt accession	P23083
Gene	IGHV1-2
Organism	Homo sapiens
Length	117 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	LOW
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (17)

Diseases linked to this target (Open Targets).

cutaneous Leishmaniasis · score 0.59
Barrett's esophagus · score 0.06
esophageal adenocarcinoma · score 0.05
sebaceous of Jadassohn nevus · score 0.04
squamous cell carcinoma · score 0.04
Crohn's disease · score 0.02
central nervous system cancer · score 0.02
infection · score 0.01
infect · score 0.01
idiopathic pulmonary fibrosis · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P23083-F1	alphafold	PREDICTED	91.72	—

Amino-acid sequence (117 residues)

MDWTWRILFL VAAATGAHSQ VQLVQSGAEV KKPGASVKVS CKASGYTFTG YYMHWVRQAP GQGLEWMGWI NPNSGGTNYA QKFQGWVTMT RDTSISTAYM ELSRLRSDDT AVYYCAR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards