About Fibulin-1
Fibulin-1 (FBLN1) is a protein
from Homo sapiens identified by UniProt accession
P23142, 703 residues long.
MolForge cross-references it against 0 known binders and
342 disease associations.
Target properties
| Protein name | Fibulin-1 |
|---|
| UniProt accession | P23142 |
|---|
| Gene | FBLN1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 703 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (342)
Diseases linked to this target (Open Targets).
- synpolydactyly type 2 · score 0.45
- erythrocyte count · score 0.42
- hemoglobin measurement · score 0.42
- FEV/FVC ratio · score 0.41
- hematocrit · score 0.39
- FBLN1-related developmental delay-central nervous system anomaly-syndactyly syndrome · score 0.37
- body height · score 0.36
- urate measurement · score 0.33
- bone density · score 0.33
- low density lipoprotein cholesterol measurement · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P23142-F1 | alphafold | PREDICTED | 79.09 | — |
Amino-acid sequence (703 residues)
MERAAPSRRV PLPLLLLGGL ALLAAGVDAD VLLEACCADG HRMATHQKDC SLPYATESKE CRMVQEQCCH SQLEELHCAT GISLANEQDR CATPHGDNAS LEATFVKRCC HCCLLGRAAQ AQGQSCEYSL MVGYQCGQVF QACCVKSQET GDLDVGGLQE TDKIIEVEEE QEDPYLNDRC RGGGPCKQQC RDTGDEVVCS CFVGYQLLSD GVSCEDVNEC ITGSHSCRLG ESCINTVGSF RCQRDSSCGT GYELTEDNSC KDIDECESGI HNCLPDFICQ NTLGSFRCRP KLQCKSGFIQ DALGNCIDIN ECLSISAPCP IGHTCINTEG SYTCQKNVPN CGRGYHLNEE GTRCVDVDEC APPAEPCGKG HRCVNSPGSF RCECKTGYYF DGISRMCVDV NECQRYPGRL CGHKCENTLG SYLCSCSVGF RLSVDGRSCE DINECSSSPC SQECANVYGS YQCYCRRGYQ LSDVDGVTCE DIDECALPTG GHICSYRCIN IPGSFQCSCP SSGYRLAPNG RNCQDIDECV TGIHNCSINE TCFNIQGGFR CLAFECPENY RRSAATLQQE KTDTVRCIKS CRPNDVTCVF DPVHTISHTV ISLPTFREFT RPEEIIFLRA ITPPHPASQA NIIFDITEGN LRDSFDIIKR YMDGMTVGVV RQVRPIVGPF HAVLKLEMNY VVGGVVSHRN VVNVHIFVSE YWF
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