About Splicing factor, proline- and glutamine-rich
Splicing factor, proline- and glutamine-rich (SFPQ) is a protein
from Homo sapiens identified by UniProt accession
P23246, 707 residues long.
MolForge cross-references it against 0 known binders and
101 disease associations.
Target properties
| Protein name | Splicing factor, proline- and glutamine-rich |
|---|
| UniProt accession | P23246 |
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| Gene | SFPQ |
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| Organism | Homo sapiens |
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| Length | 707 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (101)
Diseases linked to this target (Open Targets).
- tuberculosis · score 0.37
- Endometrial Endometrioid Adenocarcinoma · score 0.37
- lung adenocarcinoma · score 0.32
- hepatocellular carcinoma · score 0.28
- melanoma · score 0.28
- head and neck squamous cell carcinoma · score 0.28
- acute myeloid leukemia · score 0.28
- esophageal adenocarcinoma · score 0.28
- breast carcinoma · score 0.28
- gastric carcinoma · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P23246-F1 | alphafold | PREDICTED | 67.66 | — |
Amino-acid sequence (707 residues)
MSRDRFRSRG GGGGGFHRRG GGGGRGGLHD FRSPPPGMGL NQNRGPMGPG PGQSGPKPPI PPPPPHQQQQ QPPPQQPPPQ QPPPHQPPPH PQPHQQQQPP PPPQDSSKPV VAQGPGPAPG VGSAPPASSS APPATPPTSG APPGSGPGPT PTPPPAVTSA PPGAPPPTPP SSGVPTTPPQ AGGPPPPPAA VPGPGPGPKQ GPGPGGPKGG KMPGGPKPGG GPGLSTPGGH PKPPHRGGGE PRGGRQHHPP YHQQHHQGPP PGGPGGRSEE KISDSEGFKA NLSLLRRPGE KTYTQRCRLF VGNLPADITE DEFKRLFAKY GEPGEVFINK GKGFGFIKLE SRALAEIAKA ELDDTPMRGR QLRVRFATHA AALSVRNLSP YVSNELLEEA FSQFGPIERA VVIVDDRGRS TGKGIVEFAS KPAARKAFER CSEGVFLLTT TPRPVIVEPL EQLDDEDGLP EKLAQKNPMY QKERETPPRF AQHGTFEYEY SQRWKSLDEM EKQQREQVEK NMKDAKDKLE SEMEDAYHEH QANLLRQDLM RRQEELRRME ELHNQEMQKR KEMQLRQEEE RRRREEEMMI RQREMEEQMR RQREESYSRM GYMDPRERDM RMGGGGAMNM GDPYGSGGQK FPPLGGGGGI GYEANPGVPP ATMSGSMMGS DMRTERFGQG GAGPVGGQGP RGMGPGTPAG YGRGREEYEG PNKKPRF
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