Tubulin gamma-1 chain (TUBG1)

About Tubulin gamma-1 chain

Tubulin gamma-1 chain (TUBG1) is a protein from Homo sapiens identified by UniProt accession P23258, 451 residues long. MolForge cross-references it against 0 known binders and 71 disease associations.

Target properties

Protein name	Tubulin gamma-1 chain
UniProt accession	P23258
Gene	TUBG1
Organism	Homo sapiens
Length	451 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (71)

Diseases linked to this target (Open Targets).

Genetic central nervous system malformation · score 0.74
lissencephaly spectrum disorders · score 0.37
Lissencephaly · score 0.33
ovarian cancer · score 0.23
low grade glioma · score 0.23
breast adenocarcinoma · score 0.23
genetic disorder · score 0.16
hepatocellular carcinoma · score 0.10
lymphocyte count · score 0.06
body weight · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P23258-F1	alphafold	PREDICTED	91.65	—

Amino-acid sequence (451 residues)

MPREIITLQL GQCGNQIGFE FWKQLCAEHG ISPEGIVEEF ATEGTDRKDV FFYQADDEHY IPRAVLLDLE PRVIHSILNS PYAKLYNPEN IYLSEHGGGA GNNWASGFSQ GEKIHEDIFD IIDREADGSD SLEGFVLCHS IAGGTGSGLG SYLLERLNDR YPKKLVQTYS VFPNQDEMSD VVVQPYNSLL TLKRLTQNAD CVVVLDNTAL NRIATDRLHI QNPSFSQINQ LVSTIMSAST TTLRYPGYMN NDLIGLIASL IPTPRLHFLM TGYTPLTTDQ SVASVRKTTV LDVMRRLLQP KNVMVSTGRD RQTNHCYIAI LNIIQGEVDP TQVHKSLQRI RERKLANFIP WGPASIQVAL SRKSPYLPSA HRVSGLMMAN HTSISSLFER TCRQYDKLRK REAFLEQFRK EDMFKDNFDE MDTSREIVQQ LIDEYHAATR PDYISWGTQE Q

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards