Peptidyl-prolyl cis-trans isomerase B (PPIB)

About Peptidyl-prolyl cis-trans isomerase B

Peptidyl-prolyl cis-trans isomerase B (PPIB) is a protein from Homo sapiens identified by UniProt accession P23284, 216 residues long. MolForge cross-references it against 0 known binders and 1,176 disease associations.

Target properties

Protein name	Peptidyl-prolyl cis-trans isomerase B
UniProt accession	P23284
Gene	PPIB
Organism	Homo sapiens
Length	216 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (1176)

Diseases linked to this target (Open Targets).

osteogenesis imperfecta · score 0.54
osteogenesis imperfecta type 4 · score 0.38
osteogenesis imperfecta type 3 · score 0.38
osteogenesis imperfecta type 2 · score 0.38
Skeletal dysplasia · score 0.37
severe acute respiratory syndrome · score 0.37
breast adenocarcinoma · score 0.23
genetic disorder · score 0.19
mean platelet volume · score 0.18
monocyte count · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P23284-F1	alphafold	PREDICTED	91.80	—

Amino-acid sequence (216 residues)

MLRLSERNMK VLLAAALIAG SVFFLLLPGP SAADEKKKGP KVTVKVYFDL RIGDEDVGRV IFGLFGKTVP KTVDNFVALA TGEKGFGYKN SKFHRVIKDF MIQGGDFTRG DGTGGKSIYG ERFPDENFKL KHYGPGWVSM ANAGKDTNGS QFFITTVKTA WLDGKHVVFG KVLEGMEVVR KVESTKTDSR DKPLKDVIIA DCGKIEVEKP FAIAKE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards