About Sarcoplasmic reticulum histidine-rich calcium-binding protein
Sarcoplasmic reticulum histidine-rich calcium-binding protein (HRC) is a protein
from Homo sapiens identified by UniProt accession
P23327, 699 residues long.
MolForge cross-references it against 0 known binders and
160 disease associations.
Target properties
| Protein name | Sarcoplasmic reticulum histidine-rich calcium-binding protein |
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| UniProt accession | P23327 |
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| Gene | HRC |
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| Organism | Homo sapiens |
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| Length | 699 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (160)
Diseases linked to this target (Open Targets).
- body mass index · score 0.11
- hepatocellular carcinoma · score 0.09
- systolic blood pressure · score 0.08
- Arrhythmogenic right ventricular dysplasia · score 0.08
- hypertrophic cardiomyopathy · score 0.08
- Brugada syndrome · score 0.07
- Romano-Ward syndrome · score 0.07
- familial atrial fibrillation · score 0.07
- Familial short QT syndrome · score 0.06
- dilated cardiomyopathy · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P23327-F1 | alphafold | PREDICTED | 50.28 | — |
Amino-acid sequence (699 residues)
MGHHRPWLHA SVLWAGVASL LLPPAMTQQL RGDGLGFRNR NNSTGVAGLS EEASAELRHH LHSPRDHPDE NKDVSTENGH HFWSHPDREK EDEDVSKEYG HLLPGHRSQD HKVGDEGVSG EEVFAEHGGQ ARGHRGHGSE DTEDSAEHRH HLPSHRSHSH QDEDEDEVVS SEHHHHILRH GHRGHDGEDD EGEEEEEEEE EEEEASTEYG HQAHRHRGHG SEEDEDVSDG HHHHGPSHRH QGHEEDDDDD DDDDDDDDDD DVSIEYRHQA HRHQGHGIEE DEDVSDGHHH RDPSHRHRSH EEDDNDDDDV STEYGHQAHR HQDHRKEEVE AVSGEHHHHV PDHRHQGHRD EEEDEDVSTE RWHQGPQHVH HGLVDEEEEE EEITVQFGHY VASHQPRGHK SDEEDFQDEY KTEVPHHHHH RVPREEDEEV SAELGHQAPS HRQSHQDEET GHGQRGSIKE MSHHPPGHTV VKDRSHLRKD DSEEEKEKEE DPGSHEEDDE SSEQGEKGTH HGSRDQEDEE DEEEGHGLSL NQEEEEEEDK EEEEEEEDEE RREERAEVGA PLSPDHSEEE EEEEEGLEED EPRFTIIPNP LDRREEAGGA SSEEESGEDT GPQDAQEYGN YQPGSLCGYC SFCNRCTECE SCHCDEENMG EHCDQCQHCQ FCYLCPLVCE TVCAPGSYVD YFSSSLYQAL ADMLETPEP
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