About Anosmin-1
Anosmin-1 (ANOS1) is a protein
from Homo sapiens identified by UniProt accession
P23352, 680 residues long.
MolForge cross-references it against 0 known binders and
143 disease associations.
Target properties
| Protein name | Anosmin-1 |
|---|
| UniProt accession | P23352 |
|---|
| Gene | ANOS1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 680 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (143)
Diseases linked to this target (Open Targets).
- hypogonadotropic hypogonadism 1 with or without anosmia · score 0.81
- Kallmann syndrome · score 0.74
- genetic disorder · score 0.41
- congenital anomaly of kidney and urinary tract · score 0.37
- Micropenis · score 0.34
- Cataract - intellectual disability - hypogonadism · score 0.34
- hypogonadotropic hypogonadism · score 0.30
- Delayed puberty · score 0.27
- lung adenocarcinoma · score 0.24
- cutaneous melanoma · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P23352-F1 | alphafold | PREDICTED | 76.40 | — |
Amino-acid sequence (680 residues)
MVPGVPGAVL TLCLWLAASS GCLAAGPGAA AARRLDESLS AGSVQRARCA SRCLSLQITR ISAFFQHFQN NGSLVWCQNH KQCSKCLEPC KESGDLRKHQ CQSFCEPLFP KKSYECLTSC EFLKYILLVK QGDCPAPEKA SGFAAACVES CEVDNECSGV KKCCSNGCGH TCQVPKTLYK GVPLKPRKEL RFTELQSGQL EVKWSSKFNI SIEPVIYVVQ RRWNYGIHPS EDDATHWQTV AQTTDERVQL TDIRPSRWYQ FRVAAVNVHG TRGFTAPSKH FRSSKDPSAP PAPANLRLAN STVNSDGSVT VTIVWDLPEE PDIPVHHYKV FWSWMVSSKS LVPTKKKRRK TTDGFQNSVI LEKLQPDCDY VVELQAITYW GQTRLKSAKV SLHFTSTHAT NNKEQLVKTR KGGIQTQLPF QRRRPTRPLE VGAPFYQDGQ LQVKVYWKKT EDPTVNRYHV RWFPEACAHN RTTGSEASSG MTHENYIILQ DLSFSCKYKV TVQPIRPKSH SKAEAVFFTT PPCSALKGKS HKPVGCLGEA GHVLSKVLAK PENLSASFIV QDVNITGHFS WKMAKANLYQ PMTGFQVTWA EVTTESRQNS LPNSIISQSQ ILPSDHYVLT VPNLRPSTLY RLEVQVLTPG GEGPATIKTF RTPELPPSSA HRSHLKHRHP HHYKPSPERY
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