About NAD-dependent malic enzyme, mitochondrial
NAD-dependent malic enzyme, mitochondrial (ME2) is a protein
from Homo sapiens identified by UniProt accession
P23368, 584 residues long.
MolForge cross-references it against 0 known binders and
67 disease associations.
Target properties
| Protein name | NAD-dependent malic enzyme, mitochondrial |
|---|
| UniProt accession | P23368 |
|---|
| Gene | ME2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 584 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (67)
Diseases linked to this target (Open Targets).
- eosinophil percentage of leukocytes · score 0.29
- eosinophil count · score 0.24
- leukocyte count · score 0.12
- glioblastoma multiforme · score 0.09
- neoplasm · score 0.08
- hepatocellular carcinoma · score 0.08
- breast cancer · score 0.07
- oral squamous cell carcinoma · score 0.07
- blood pressure · score 0.07
- apolipoprotein A 1 measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P23368-F1 | alphafold | PREDICTED | 94.36 | — |
Amino-acid sequence (584 residues)
MLSRLRVVST TCTLACRHLH IKEKGKPLML NPRTNKGMAF TLQERQMLGL QGLLPPKIET QDIQALRFHR NLKKMTSPLE KYIYIMGIQE RNEKLFYRIL QDDIESLMPI VYTPTVGLAC SQYGHIFRRP KGLFISISDR GHVRSIVDNW PENHVKAVVV TDGERILGLG DLGVYGMGIP VGKLCLYTAC AGIRPDRCLP VCIDVGTDNI ALLKDPFYMG LYQKRDRTQQ YDDLIDEFMK AITDRYGRNT LIQFEDFGNH NAFRFLRKYR EKYCTFNDDI QGTAAVALAG LLAAQKVISK PISEHKILFL GAGEAALGIA NLIVMSMVEN GLSEQEAQKK IWMFDKYGLL VKGRKAKIDS YQEPFTHSAP ESIPDTFEDA VNILKPSTII GVAGAGRLFT PDVIRAMASI NERPVIFALS NPTAQAECTA EEAYTLTEGR CLFASGSPFG PVKLTDGRVF TPGQGNNVYI FPGVALAVIL CNTRHISDSV FLEAAKALTS QLTDEELAQG RLYPPLANIQ EVSINIAIKV TEYLYANKMA FRYPEPEDKA KYVKERTWRS EYDSLLPDVY EWPESASSPP VITE
Explore NAD-dependent malic enzyme, mitochondrial with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets