About Tryptophan--tRNA ligase, cytoplasmic
Tryptophan--tRNA ligase, cytoplasmic (WARS1) is a protein
from Homo sapiens identified by UniProt accession
P23381, 471 residues long.
MolForge cross-references it against 0 known binders and
242 disease associations.
Target properties
| Protein name | Tryptophan--tRNA ligase, cytoplasmic |
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| UniProt accession | P23381 |
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| Gene | WARS1 |
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| Organism | Homo sapiens |
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| Length | 471 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (242)
Diseases linked to this target (Open Targets).
- neurodevelopmental disorder with microcephaly and speech delay, with or without brain abnormalities · score 0.55
- neuronopathy, distal hereditary motor, autosomal dominant · score 0.45
- distal hereditary motor neuropathy · score 0.38
- autosomal recessive primary microcephaly · score 0.37
- complex neurodevelopmental disorder · score 0.37
- glucose measurement · score 0.27
- blood protein measurement · score 0.26
- testosterone measurement · score 0.24
- mean arterial pressure · score 0.23
- systolic blood pressure · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P23381-F1 | alphafold | PREDICTED | 91.61 | — |
Amino-acid sequence (471 residues)
MPNSEPASLL ELFNSIATQG ELVRSLKAGN ASKDEIDSAV KMLVSLKMSY KAAAGEDYKA DCPPGNPAPT SNHGPDATEA EEDFVDPWTV QTSSAKGIDY DKLIVRFGSS KIDKELINRI ERATGQRPHH FLRRGIFFSH RDMNQVLDAY ENKKPFYLYT GRGPSSEAMH VGHLIPFIFT KWLQDVFNVP LVIQMTDDEK YLWKDLTLDQ AYSYAVENAK DIIACGFDIN KTFIFSDLDY MGMSSGFYKN VVKIQKHVTF NQVKGIFGFT DSDCIGKISF PAIQAAPSFS NSFPQIFRDR TDIQCLIPCA IDQDPYFRMT RDVAPRIGYP KPALLHSTFF PALQGAQTKM SASDPNSSIF LTDTAKQIKT KVNKHAFSGG RDTIEEHRQF GGNCDVDVSF MYLTFFLEDD DKLEQIRKDY TSGAMLTGEL KKALIEVLQP LIAEHQARRK EVTDEIVKEF MTPRKLSFDF Q
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