About Small ribosomal subunit protein uS3
Small ribosomal subunit protein uS3 (RPS3) is a protein
from Homo sapiens identified by UniProt accession
P23396, 243 residues long.
MolForge cross-references it against 0 known binders and
120 disease associations.
Target properties
| Protein name | Small ribosomal subunit protein uS3 |
|---|
| UniProt accession | P23396 |
|---|
| Gene | RPS3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 243 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (120)
Diseases linked to this target (Open Targets).
- Duchenne muscular dystrophy · score 0.50
- cystic fibrosis · score 0.50
- influenza · score 0.46
- COVID-19 · score 0.37
- severe acute respiratory syndrome · score 0.37
- Becker muscular dystrophy · score 0.29
- clear cell renal carcinoma · score 0.27
- endometrial cancer · score 0.27
- qualitative or quantitative defects of dystrophin · score 0.26
- neurodegenerative disease · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P23396-F1 | alphafold | PREDICTED | 91.05 | — |
Amino-acid sequence (243 residues)
MAVQISKKRK FVADGIFKAE LNEFLTRELA EDGYSGVEVR VTPTRTEIII LATRTQNVLG EKGRRIRELT AVVQKRFGFP EGSVELYAEK VATRGLCAIA QAESLRYKLL GGLAVRRACY GVLRFIMESG AKGCEVVVSG KLRGQRAKSM KFVDGLMIHS GDPVNYYVDT AVRHVLLRQG VLGIKVKIML PWDPTGKIGP KKPLPDHVSI VEPKDEILPT TPISEQKGGK PEPPAMPQPV PTA
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