About Glycine cleavage system H protein, mitochondrial
Glycine cleavage system H protein, mitochondrial (GCSH) is a protein
from Homo sapiens identified by UniProt accession
P23434, 173 residues long.
MolForge cross-references it against 0 known binders and
133 disease associations.
Target properties
| Protein name | Glycine cleavage system H protein, mitochondrial |
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| UniProt accession | P23434 |
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| Gene | GCSH |
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| Organism | Homo sapiens |
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| Length | 173 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (133)
Diseases linked to this target (Open Targets).
- glycine encephalopathy · score 0.71
- glycine measurement · score 0.50
- neurodegenerative disease · score 0.48
- infantile glycine encephalopathy · score 0.37
- atypical glycine encephalopathy · score 0.37
- neonatal glycine encephalopathy · score 0.37
- serum metabolite measurement · score 0.31
- lysosomal storage disease · score 0.22
- genetic disorder · score 0.19
- Myopia · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P23434-F1 | alphafold | PREDICTED | 85.02 | — |
Amino-acid sequence (173 residues)
MALRVVRSVR ALLCTLRAVP SPAAPCPPRP WQLGVGAVRT LRTGPALLSV RKFTEKHEWV TTENGIGTVG ISNFAQEALG DVVYCSLPEV GTKLNKQDEF GALESVKAAS ELYSPLSGEV TEINEALAEN PGLVNKSCYE DGWLIKMTLS NPSELDELMS EEAYEKYIKS IEE
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