About Ribosomal protein S6 kinase beta-1
Ribosomal protein S6 kinase beta-1 (RPS6KB1) is a protein
from Homo sapiens identified by UniProt accession
P23443, 525 residues long.
MolForge cross-references it against 0 known binders and
598 disease associations.
Target properties
| Protein name | Ribosomal protein S6 kinase beta-1 |
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| UniProt accession | P23443 |
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| Gene | RPS6KB1 |
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| Organism | Homo sapiens |
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| Length | 525 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (8)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (598)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.51
- neuroinflammatory disorder · score 0.37
- Red cell distribution width · score 0.34
- pulse pressure measurement · score 0.34
- inflammatory bowel disease · score 0.30
- C-reactive protein measurement · score 0.29
- Crohn's disease · score 0.29
- bilirubin measurement · score 0.29
- breast adenocarcinoma · score 0.28
- systolic blood pressure · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P23443-F1 | alphafold | PREDICTED | 72.16 | — |
Amino-acid sequence (525 residues)
MRRRRRRDGF YPAPDFRDRE AEDMAGVFDI DLDQPEDAGS EDELEEGGQL NESMDHGGVG PYELGMEHCE KFEISETSVN RGPEKIRPEC FELLRVLGKG GYGKVFQVRK VTGANTGKIF AMKVLKKAMI VRNAKDTAHT KAERNILEEV KHPFIVDLIY AFQTGGKLYL ILEYLSGGEL FMQLEREGIF MEDTACFYLA EISMALGHLH QKGIIYRDLK PENIMLNHQG HVKLTDFGLC KESIHDGTVT HTFCGTIEYM APEILMRSGH NRAVDWWSLG ALMYDMLTGA PPFTGENRKK TIDKILKCKL NLPPYLTQEA RDLLKKLLKR NAASRLGAGP GDAGEVQAHP FFRHINWEEL LARKVEPPFK PLLQSEEDVS QFDSKFTRQT PVDSPDDSTL SESANQVFLG FTYVAPSVLE SVKEKFSFEP KIRSPRRFIG SPRTPVSPVK FSPGDFWGRG ASASTANPQT PVEYPMETSG IEQMDVTMSG EASAPLPIRQ PNSGPYKKQA FPMISKRPEH LRMNL
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