About Loricrin
Loricrin (LORICRIN) is a protein
from Homo sapiens identified by UniProt accession
P23490, 312 residues long.
MolForge cross-references it against 0 known binders and
120 disease associations.
Target properties
| Protein name | Loricrin |
|---|
| UniProt accession | P23490 |
|---|
| Gene | LORICRIN |
|---|
| Organism | Homo sapiens |
|---|
| Length | 312 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (120)
Diseases linked to this target (Open Targets).
- Keratoderma hereditarium mutilans with ichthyosis · score 0.62
- loricrin keratoderma · score 0.58
- abscess · score 0.06
- balding measurement · score 0.06
- erythrokeratodermia variabilis · score 0.05
- peeling skin syndrome 6 · score 0.04
- hepatorenocardiac degenerative fibrosis · score 0.04
- Ichthyosis-hypotrichosis syndrome · score 0.04
- Senior-Boichis syndrome · score 0.04
- hidradenitis suppurativa · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P23490-F1 | alphafold | PREDICTED | 43.10 | — |
Amino-acid sequence (312 residues)
MSYQKKQPTP QPPVDCVKTS GGGGGGGGSG GGGCGFFGGG GSGGGSSGSG CGYSGGGGYS GGGCGGGSSG GGGGGGIGGC GGGSGGSVKY SGGGGSSGGG SGCFSSGGGG SGCFSSGGGG SSGGGSGCFS SGGGGSSGGG SGCFSSGGGG FSGQAVQCQS YGGVSSGGSS GGGSGCFSSG GGGGSVCGYS GGGSGCGGGS SGGSGSGYVS SQQVTQTSCA PQPSYGGGSS GGGGSGGSGC FSSGGGGGSS GCGGGSSGIG SGCIISGGGS VCGGGSSGGG GGGSSVGGSG SGKGVPICHQ TQQKQAPTWP SK
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