Nuclear transcription factor Y subunit alpha (NFYA)

About Nuclear transcription factor Y subunit alpha

Nuclear transcription factor Y subunit alpha (NFYA) is a protein from Homo sapiens identified by UniProt accession P23511, 347 residues long. MolForge cross-references it against 0 known binders and 114 disease associations.

Target properties

Protein name	Nuclear transcription factor Y subunit alpha
UniProt accession	P23511
Gene	NFYA
Organism	Homo sapiens
Length	347 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (114)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.33
mean corpuscular volume · score 0.14
neoplasm · score 0.09
blood protein measurement · score 0.08
triple-negative breast cancer · score 0.08
osteosarcoma · score 0.07
non-small cell lung carcinoma · score 0.06
hepatocellular carcinoma · score 0.05
family history of Alzheimer’s disease · score 0.05
Alzheimer disease · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P23511-F1	alphafold	PREDICTED	49.39	—

Amino-acid sequence (347 residues)

MEQYTANSNS STEQIVVQAG QIQQQQQGGV TAVQLQTEAQ VASASGQQVQ TLQVVQGQPL MVQVSGGQLI TSTGQPIMVQ AVPGGQGQTI MQVPVSGTQG LQQIQLVPPG QIQIQGGQAV QVQGQQGQTQ QIIIQQPQTA VTAGQTQTQQ QIAVQGQQVA QTAEGQTIVY QPVNADGTIL QQVTVPVSGM ITIPAASLAG AQIVQTGANT NTTSSGQGTV TVTLPVAGNV VNSGGMVMMV PGAGSVPAIQ RIPLPGAEML EEEPLYVNAK QYHRILKRRQ ARAKLEAEGK IPKERRKYLH ESRHRHAMAR KRGEGGRFFS PKEKDSPHMQ DPNQADEEAM TQIIRVS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards