Oligodendrocyte-myelin glycoprotein (OMG)

About Oligodendrocyte-myelin glycoprotein

Oligodendrocyte-myelin glycoprotein (OMG) is a protein from Homo sapiens identified by UniProt accession P23515, 440 residues long. MolForge cross-references it against 0 known binders and 83 disease associations.

Target properties

Protein name	Oligodendrocyte-myelin glycoprotein
UniProt accession	P23515
Gene	OMG
Organism	Homo sapiens
Length	440 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (83)

Diseases linked to this target (Open Targets).

neurofibromatosis type 1 · score 0.34
risk-taking behaviour · score 0.28
diet measurement · score 0.22
feeling nervous measurement · score 0.22
worry measurement · score 0.22
serum gamma-glutamyl transferase measurement · score 0.22
apolipoprotein B measurement · score 0.21
sex hormone-binding globulin measurement · score 0.20
low density lipoprotein cholesterol measurement · score 0.19
total cholesterol measurement · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P23515-F1	alphafold	PREDICTED	66.97	—

Amino-acid sequence (440 residues)

MEYQILKMSL CLFILLFLTP GILCICPLQC ICTERHRHVD CSGRNLSTLP SGLQENIIHL NLSYNHFTDL HNQLTQYTNL RTLDISNNRL ESLPAHLPRS LWNMSAANNN IKLLDKSDTA YQWNLKYLDV SKNMLEKVVL IKNTLRSLEV LNLSSNKLWT VPTNMPSKLH IVDLSNNSLT QILPGTLINL TNLTHLYLHN NKFTFIPDQS FDQLFQLQEI TLYNNRWSCD HKQNITYLLK WMMETKAHVI GTPCSTQISS LKEHNMYPTP SGFTSSLFTV SGMQTVDTIN SLSVVTQPKV TKIPKQYRTK ETTFGATLSK DTTFTSTDKA FVPYPEDTST ETINSHEAAA ATLTIHLQDG MVTNTSLTSS TKSSPTPMTL SITSGMPNNF SEMPQQSTTL NLWREETTTN VKTPLPSVAN AWKVNASFLL LLNVVVMLAV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards